Anesthesia
Pain management and sedation techniques
Angiology
Arterial and venous pathologies
Cardiology
Acquired and congenital heart diseases
Dentistry
Diseases of teeth, gums, and the oral cavity
Dermatology
Disorders of the skin and subcutaneous tissue
Endocrinology
Disorders of the glands and hormonal imbalance
Gastroenterology
Stomach, intestinal, and digestive diseases
Gynecology
Diseases of female reproductive organs
Hepatology
Liver, gallbladder, and biliary tract diseases
Neurology
Brain, spinal cord, and peripheral nerve disorders
Obstetrics
Pregnancy complications and abnormal fetal positions
Oncology
Cancer types, benign and malignant tumors
Ophthalmology
Conditions affecting the eyes and vision
Otorhinolaryngology
Ear, nose, and throat diseases
Pediatrics
Child health, development, and clinical conditions
Pulmonology
Lung and respiratory tract diseases
Traumatology
Acute injuries and musculoskeletal trauma
Anesthesia
Pain management and sedation techniques
Angiology
Arterial and venous pathologies
Cardiology
Acquired and congenital heart diseases
Dentistry
Diseases of teeth, gums, and the oral cavity
Dermatology
Disorders of the skin and subcutaneous tissue
Endocrinology
Disorders of the glands and hormonal imbalance
Gastroenterology
Stomach, intestinal, and digestive diseases
Gynecology
Diseases of female reproductive organs
Hepatology
Liver, gallbladder, and biliary tract diseases
Neurology
Brain, spinal cord, and peripheral nerve disorders
Obstetrics
Pregnancy complications and abnormal fetal positions
Oncology
Cancer types, benign and malignant tumors
Ophthalmology
Conditions affecting the eyes and vision
Otorhinolaryngology
Ear, nose, and throat diseases
Pediatrics
Child health, development, and clinical conditions
Pulmonology
Lung and respiratory tract diseases
Traumatology
Acute injuries and musculoskeletal trauma
Granulation tissue (Latin: granulum) is a young connective tissue rich in blood vessels and immune system cells. In dentistry, the formation of this tissue is the body’s universal response to chronic inflammation at the root tip of the tooth.
Etiology and pathophysiology
When infection is constantly coming from the root canal, the bone tissue of the jaw is destroyed and replaced by granulation tissue. This tissue has a protective function: blood vessels deliver immune system cells to the site of infection to fight microorganisms. Over time, the granulation tissue may increase in volume, leading to the formation of a granuloma.
Clinical significance
On X-ray, granulation tissue looks like a darkened area (dark spot). After successful endodontic treatment and elimination of biofilm in the root canals, granulation is gradually transformed into full-fledged bone tissue, which is a sign of healing.