{"id":7450,"date":"2026-07-23T14:02:20","date_gmt":"2026-07-23T11:02:20","guid":{"rendered":"https:\/\/wiki.voka.io\/glossary\/sepse-neonatal\/"},"modified":"2026-07-23T14:02:18","modified_gmt":"2026-07-23T11:02:18","slug":"sepse-neonatal","status":"publish","type":"glossary_item","link":"https:\/\/wiki.voka.io\/pt\/glossario\/sepse-neonatal\/","title":{"rendered":"Sepse neonatal"},"content":{"rendered":"\n

A sepse neonatal (do grego n\u0113os<\/em> \u2014 novo, do latim natus<\/em> \u2014 nascimento e do grego sepsis<\/em> \u2014 putrefa\u00e7\u00e3o) \u00e9 uma condi\u00e7\u00e3o com risco de vida, representando uma rea\u00e7\u00e3o inflamat\u00f3ria sist\u00eamica generalizada do organismo do rec\u00e9m-nascido em resposta \u00e0 entrada de um agente infeccioso na corrente sangu\u00ednea.<\/p>\n\n

Etiologia e fisiopatologia<\/strong><\/h2>\n\n

A doen\u00e7a \u00e9 classificada em septicemia de in\u00edcio precoce (nas primeiras 72 horas de vida) e de in\u00edcio tardio.<\/p>\n\n

A septicemia de in\u00edcio precoce est\u00e1 frequentemente associada \u00e0 transmiss\u00e3o vertical: o rec\u00e9m-nascido \u00e9 infectado intra\u00fatero ou geralmente no momento da passagem pelo canal de parto infectado da m\u00e3e (pat\u00f3genos t\u00edpicos \u2014 estreptococo do grupo B, Escherichia coli).<\/p>\n\n

A patog\u00eanese \u00e9 devida \u00e0 insufici\u00eancia das barreiras mucosas e \u00e0 imaturidade fisiol\u00f3gica do sistema imunol\u00f3gico do rec\u00e9m-nascido. Os fatores de vulnerabilidade incluem:<\/p>\n\n

    \n
  • diminui\u00e7\u00e3o da atividade fagocit\u00e1ria dos leuc\u00f3citos;<\/li>\n\n\n\n
  • baixos n\u00edveis de T-helpers e a sua “ingenuidade”;<\/li>\n\n\n\n
  • baixos n\u00edveis de IgM e IgA.<\/li>\n<\/ul>\n\n

    Como resultado, o pat\u00f3geno rompe rapidamente as barreiras de defesa locais e entra na corrente sangu\u00ednea (bacteremia).<\/p>\n\n

    O organismo responde com uma potente libera\u00e7\u00e3o de citocinas pr\u00f3-inflamat\u00f3rias (“tempestade de citocinas”), que pode levar ao desenvolvimento de choque devido \u00e0 ativa\u00e7\u00e3o do sistema complemento e \u00e0 ativa\u00e7\u00e3o interna da hemostasia.<\/p>\n\n

    Import\u00e2ncia cl\u00ednica<\/strong><\/h2>\n\n

    A septicemia neonatal caracteriza-se por um curso r\u00e1pido e por vezes fulminante e alta letalidade. O quadro cl\u00ednico em rec\u00e9m-nascidos \u00e9 frequentemente at\u00edpico.<\/p>\n\n

    Em vez de febre cl\u00e1ssica, podem ser observados os seguintes sintomas:<\/p>\n\n

      \n
    • hipotermia (diminui\u00e7\u00e3o da temperatura corporal) ou flutua\u00e7\u00f5es de temperatura;<\/li>\n\n\n\n
    • letargia acentuada;<\/li>\n\n\n\n
    • m\u00e1 suc\u00e7\u00e3o ou recusa alimentar;<\/li>\n\n\n\n
    • per\u00edodos de apneia (paradas respirat\u00f3rias);<\/li>\n\n\n\n
    • bradicardia;<\/li>\n\n\n\n
    • marmoriza\u00e7\u00e3o da pele devido a problemas na microcircula\u00e7\u00e3o.<\/li>\n<\/ul>\n\n

      Na menor suspeita de septicemia, os m\u00e9dicos iniciam imediatamente a terapia antibacteriana intravenosa emp\u00edrica combinada com antibi\u00f3ticos de amplo espectro, sem esperar pelos resultados dos cultivos de sangue (que podem levar v\u00e1rios dias).<\/p>\n","protected":false},"excerpt":{"rendered":"

      A sepse neonatal (do grego n\u0113os<\/em> \u2014 novo, do latim natus<\/em> \u2014 nascimento e do grego sepsis<\/em> \u2014 putrefa\u00e7\u00e3o) \u00e9 uma condi\u00e7\u00e3o com risco de vida, representando uma rea\u00e7\u00e3o inflamat\u00f3ria sist\u00eamica generalizada do organismo do rec\u00e9m-nascido em resposta \u00e0 entrada de um agente infeccioso na corrente sangu\u00ednea.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-7450","glossary_item","type-glossary_item","status-publish","hentry"],"acf":[],"yoast_head":"\nSepse neonatal: defini\u00e7\u00e3o m\u00e9dica e vis\u00e3o geral | Voka Wiki<\/title>\n<meta name=\"description\" content=\"A sepse neonatal (do grego n\u0113os \u2014 novo, do latim natus \u2014 nascimento e do grego sepsis \u2014 putrefa\u00e7\u00e3o) \u00e9 uma condi\u00e7\u00e3o com risco de vida, representando uma rea\u00e7\u00e3o inflamat\u00f3ria sist\u00eamica generalizada do organismo do rec\u00e9m-nascido em 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