{"id":3933,"date":"2026-02-26T16:53:46","date_gmt":"2026-02-26T13:53:46","guid":{"rendered":"https:\/\/wiki.voka.io\/glossary\/agonistas-gnrh\/"},"modified":"2026-04-01T18:38:35","modified_gmt":"2026-04-01T15:38:35","slug":"agonistas-gnrh","status":"publish","type":"glossary_item","link":"https:\/\/wiki.voka.io\/pt\/glossary\/agonistas-gnrh\/","title":{"rendered":"Agonistas de GnRH"},"content":{"rendered":"\n<p>Os agonistas de GnRH s\u00e3o uma classe de medicamentos pept\u00eddicos sint\u00e9ticos (triptorelina, goserelina, buserelina), que s\u00e3o an\u00e1logos estruturais do horm\u00f4nio liberador de gonadotropina natural do hipot\u00e1lamo, mas possuem maior afinidade pelos receptores e resist\u00eancia \u00e0 degrada\u00e7\u00e3o enzim\u00e1tica.<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x44D;&#x442;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;-&#x438;-&#x43F;&#x430;&#x442;&#x43E;&#x444;&#x438;&#x437;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;\"><strong>Etiologia e fisiopatologia<\/strong><\/h2>\n\n<p>Em condi\u00e7\u00f5es fisiol\u00f3gicas, o GnRH \u00e9 secretado pelo hipot\u00e1lamo em modo puls\u00e1til (a cada 90 minutos), estimulando a libera\u00e7\u00e3o de FSH e LH pela pituit\u00e1ria. A administra\u00e7\u00e3o de formas-dep\u00f3sito dos agonistas cria uma concentra\u00e7\u00e3o sangu\u00ednea elevada e constante do horm\u00f4nio. Isso implementa um mecanismo de a\u00e7\u00e3o bif\u00e1sico:<\/p>\n\n<ol class=\"wp-block-list\">\n<li><strong>Fase de estimula\u00e7\u00e3o (flare-up):<\/strong> nos primeiros 3\u20137 dias, ocorre uma libera\u00e7\u00e3o tempor\u00e1ria de gonadotrofinas e estradiol.<\/li>\n\n\n\n<li><strong>Fase de dessensibiliza\u00e7\u00e3o (down-regulation):<\/strong> ap\u00f3s 10\u201314 dias, os receptores da pituit\u00e1ria perdem a sensibilidade e &#8220;mergulham&#8221; para dentro da c\u00e9lula. A secre\u00e7\u00e3o de FSH e LH \u00e9 bloqueada, os ov\u00e1rios suspendem a fun\u00e7\u00e3o, e o n\u00edvel de estradiol cai para valores de castra\u00e7\u00e3o (menopausa induzida revers\u00edvel).<\/li>\n<\/ol>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x43A;&#x43B;&#x438;&#x43D;&#x438;&#x447;&#x435;&#x441;&#x43A;&#x43E;&#x435;-&#x437;&#x43D;&#x430;&#x447;&#x435;&#x43D;&#x438;&#x435;\"><strong>Import\u00e2ncia cl\u00ednica<\/strong><\/h2>\n\n<p>Os agonistas de GnRH s\u00e3o a terapia mais potente para doen\u00e7as dependentes de horm\u00f4nios. A hipoestrogenia profunda causa atrofia dos focos de <strong>endometriose<\/strong>, al\u00edvio da dor p\u00e9lvica e redu\u00e7\u00e3o no volume do \u00fatero e dos n\u00f3dulos de <strong>mioma<\/strong> em 30\u201350%. S\u00e3o usados em protocolos de FIV para prevenir a ovula\u00e7\u00e3o prematura. A dura\u00e7\u00e3o da monoterapia \u00e9 limitada a 6 meses devido ao risco de desenvolvimento de osteoporose.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Os agonistas de GnRH s\u00e3o uma classe de medicamentos pept\u00eddicos sint\u00e9ticos (triptorelina, goserelina, buserelina), que s\u00e3o an\u00e1logos estruturais do horm\u00f4nio liberador de gonadotropina natural do hipot\u00e1lamo, mas possuem maior afinidade pelos receptores e resist\u00eancia \u00e0 degrada\u00e7\u00e3o enzim\u00e1tica.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-3933","glossary_item","type-glossary_item","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.0 (Yoast SEO v26.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Agonistas de GnRH: defini\u00e7\u00e3o m\u00e9dica e vis\u00e3o geral | Voka Wiki<\/title>\n<meta name=\"description\" content=\"Os agonistas de GnRH s\u00e3o uma 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