{"id":3445,"date":"2026-02-26T16:53:47","date_gmt":"2026-02-26T13:53:47","guid":{"rendered":"https:\/\/wiki.voka.io\/glossary\/reacao-de-jarisch-herxheimer\/"},"modified":"2026-02-26T16:53:49","modified_gmt":"2026-02-26T13:53:49","slug":"reacao-de-jarisch-herxheimer","status":"publish","type":"glossary_item","link":"https:\/\/wiki.voka.io\/pt\/glossario\/reacao-de-jarisch-herxheimer\/","title":{"rendered":"A rea\u00e7\u00e3o de Jarisch-Herxheimer"},"content":{"rendered":"\n<p>A rea\u00e7\u00e3o de Jarisch-Gerxheimer (segundo os nomes dos dermatologistas austr\u00edacos e alem\u00e3es que descreveram o fen\u00f3meno) \u00e9 uma rea\u00e7\u00e3o imunit\u00e1ria sist\u00e9mica transit\u00f3ria do organismo que se desenvolve nas primeiras 24 horas ap\u00f3s o in\u00edcio de uma terapia antibi\u00f3tica espec\u00edfica para infec\u00e7\u00f5es por espiroquetas (s\u00edfilis, borreliose, leptospirose).<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x44D;&#x442;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;-&#x438;-&#x43F;&#x430;&#x442;&#x43E;&#x444;&#x438;&#x437;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;\"><strong>Etiologia e fisiopatologia<\/strong><\/h2>\n\n<p>A patog\u00e9nese da rea\u00e7\u00e3o n\u00e3o \u00e9 al\u00e9rgica (n\u00e3o se trata de anafilaxia \u00e0 penicilina). A condi\u00e7\u00e3o \u00e9 causada pela r\u00e1pida bacteri\u00f3lise (destrui\u00e7\u00e3o) das espiroquetas sob a a\u00e7\u00e3o do antibi\u00f3tico. Quando as bact\u00e9rias morrem em massa, as endotoxinas, as lipoprote\u00ednas e os fragmentos de ADN s\u00e3o libertados de imediato na corrente sangu\u00ednea. Isto provoca uma resposta imunit\u00e1ria sist\u00e9mica &#8211; uma &#8220;tempestade de citocinas&#8221; com um aumento acentuado do n\u00edvel do fator de necrose tumoral (TNF-\u03b1), das interleucinas IL-6 e IL-8.   <\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x43A;&#x43B;&#x438;&#x43D;&#x438;&#x447;&#x435;&#x441;&#x43A;&#x43E;&#x435;-&#x437;&#x43D;&#x430;&#x447;&#x435;&#x43D;&#x438;&#x435;\"><strong>Significado cl\u00ednico<\/strong><\/h2>\n\n<p>O quadro cl\u00ednico desenvolve-se 2-8 horas ap\u00f3s a primeira inje\u00e7\u00e3o e assemelha-se a uma s\u00edndrome gripal: arrepios s\u00fabitos, aumento da temperatura corporal para 39-40\u00b0C, dor de cabe\u00e7a, mialgia, taquicardia e hipotens\u00e3o transit\u00f3ria. A <strong>s\u00edfilis<\/strong> caracteriza-se por um agravamento tempor\u00e1rio (brilho, incha\u00e7o) das erup\u00e7\u00f5es cut\u00e2neas e por um aumento da infiltra\u00e7\u00e3o na zona do cancro prim\u00e1rio ou da <strong>vaginite sifil\u00edtica<\/strong>. Esta situa\u00e7\u00e3o resolve-se por si s\u00f3 no espa\u00e7o de um dia e serve como confirma\u00e7\u00e3o indireta da efic\u00e1cia da terap\u00eautica.  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>A rea\u00e7\u00e3o de Jarisch-Gerxheimer (segundo os nomes dos dermatologistas austr\u00edacos e alem\u00e3es que descreveram o fen\u00f3meno) \u00e9 uma rea\u00e7\u00e3o imunit\u00e1ria sist\u00e9mica transit\u00f3ria do organismo que se desenvolve nas primeiras 24 horas ap\u00f3s o in\u00edcio de uma terapia antibi\u00f3tica espec\u00edfica para infec\u00e7\u00f5es por espiroquetas (s\u00edfilis, borreliose, leptospirose).<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-3445","glossary_item","type-glossary_item","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.0 (Yoast SEO v26.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A rea\u00e7\u00e3o de 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