{"id":3936,"date":"2026-02-26T16:53:46","date_gmt":"2026-02-26T13:53:46","guid":{"rendered":"https:\/\/wiki.voka.io\/glossary\/agonistes-gnrh\/"},"modified":"2026-04-01T18:38:38","modified_gmt":"2026-04-01T15:38:38","slug":"agonistes-gnrh","status":"publish","type":"glossary_item","link":"https:\/\/wiki.voka.io\/fr\/glossary\/agonistes-gnrh\/","title":{"rendered":"Agonistes de GnRH"},"content":{"rendered":"\n<p>Les agonistes de GnRH sont une classe de m\u00e9dicaments peptidiques synth\u00e9tiques (triptor\u00e9line, gos\u00e9r\u00e9line, bus\u00e9r\u00e9line) qui sont des analogues structuraux de l&rsquo;hormone naturelle de lib\u00e9ration de la gonadotrophine de l&rsquo;hypothalamus, mais avec une affinit\u00e9 plus \u00e9lev\u00e9e pour les r\u00e9cepteurs et une r\u00e9sistance \u00e0 la d\u00e9gradation enzymatique.<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x44D;&#x442;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;-&#x438;-&#x43F;&#x430;&#x442;&#x43E;&#x444;&#x438;&#x437;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;\"><strong>\u00c9tiologie et physiopathologie<\/strong><\/h2>\n\n<p>Dans des conditions physiologiques, la GnRH est s\u00e9cr\u00e9t\u00e9e par l&rsquo;hypothalamus de mani\u00e8re pulsatile (toutes les 90 minutes), ce qui stimule la lib\u00e9ration de FSH et de LH par l&rsquo;hypophyse. L&rsquo;introduction de formes retard des agonistes cr\u00e9e une concentration constante et \u00e9lev\u00e9e de l&rsquo;hormone dans le sang. Cela r\u00e9alise un m\u00e9canisme d&rsquo;action en deux phases :<\/p>\n\n<ol class=\"wp-block-list\">\n<li><strong>Phase de stimulation (flare-up) :<\/strong> dans les premiers 3 \u00e0 7 jours, il y a une br\u00e8ve pouss\u00e9e de gonadotrophines et d&rsquo;estradiol.<\/li>\n\n\n\n<li><strong>Phase de d\u00e9sensibilisation (down-regulation) :<\/strong> apr\u00e8s 10 \u00e0 14 jours, les r\u00e9cepteurs de l&rsquo;hypophyse perdent leur sensibilit\u00e9 et s&rsquo;internalisent. La s\u00e9cr\u00e9tion de FSH et de LH est bloqu\u00e9e, les ovaires cessent de fonctionner, et le niveau d&rsquo;estradiol chute \u00e0 des niveaux castrants (m\u00e9nopause m\u00e9dicale r\u00e9versible).<\/li>\n<\/ol>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x43A;&#x43B;&#x438;&#x43D;&#x438;&#x447;&#x435;&#x441;&#x43A;&#x43E;&#x435;-&#x437;&#x43D;&#x430;&#x447;&#x435;&#x43D;&#x438;&#x435;\"><strong>Importance clinique<\/strong><\/h2>\n\n<p>Les agonistes de GnRH sont la th\u00e9rapie la plus puissante pour les maladies hormonod\u00e9pendantes. L&rsquo;hypoestrog\u00e9nie profonde provoque une atrophie des l\u00e9sions <strong>d&rsquo;endom\u00e9triose<\/strong>, la r\u00e9duction de la douleur pelvienne et la diminution du volume de l&rsquo;ut\u00e9rus et des fibromes <strong>fibrome<\/strong> de 30 \u00e0 50 %. Ils sont utilis\u00e9s dans les protocoles de FIV pour pr\u00e9venir l&rsquo;ovulation pr\u00e9matur\u00e9e. La dur\u00e9e de la monoth\u00e9rapie est limit\u00e9e \u00e0 6 mois en raison du risque de d\u00e9veloppement de l&rsquo;ost\u00e9oporose.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Les agonistes de GnRH sont une classe de m\u00e9dicaments peptidiques synth\u00e9tiques (triptor\u00e9line, gos\u00e9r\u00e9line, bus\u00e9r\u00e9line) qui sont des analogues structuraux de l&rsquo;hormone naturelle de lib\u00e9ration de la gonadotrophine de l&rsquo;hypothalamus, mais avec une affinit\u00e9 plus \u00e9lev\u00e9e pour les r\u00e9cepteurs et une r\u00e9sistance \u00e0 la d\u00e9gradation enzymatique.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-3936","glossary_item","type-glossary_item","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.0 (Yoast SEO v26.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Agonistes de GnRH : d\u00e9finition m\u00e9dicale et description | 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