{"id":3928,"date":"2026-02-26T16:54:08","date_gmt":"2026-02-26T13:54:08","guid":{"rendered":"https:\/\/wiki.voka.io\/glossary\/traitement-hormonal-substitutif\/"},"modified":"2026-04-01T18:38:11","modified_gmt":"2026-04-01T15:38:11","slug":"traitement-hormonal-substitutif","status":"publish","type":"glossary_item","link":"https:\/\/wiki.voka.io\/fr\/glossary\/traitement-hormonal-substitutif\/","title":{"rendered":"Traitement hormonal substitutif"},"content":{"rendered":"\n<p>Le traitement hormonal substitutif (THS) est une strat\u00e9gie de correction pharmacologique des \u00e9tats d\u00e9ficients en \u0153strog\u00e8nes chez les femmes en p\u00e9ri- et postm\u00e9nopause. <\/p>\n\n<p>La m\u00e9thode repose sur le principe pathog\u00e9n\u00e9tique de substitution de la s\u00e9cr\u00e9tion endog\u00e8ne r\u00e9duite ou arr\u00eat\u00e9e des hormones sexuelles (\u0153strog\u00e8nes et progestag\u00e8nes) par des analogues exog\u00e8nes.<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x44D;&#x442;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;-&#x438;-&#x43F;&#x430;&#x442;&#x43E;&#x444;&#x438;&#x437;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;\"><strong>\u00c9tiologie et physiopathologie<\/strong><\/h2>\n\n<p>Avec l&rsquo;\u00e2ge, il y a un appauvrissement de l&rsquo;appareil folliculaire ovarien, ce qui conduit \u00e0 une chute critique des niveaux d&rsquo;estradiol et \u00e0 une augmentation compensatoire des gonadotrophines (FSH). Les r\u00e9cepteurs d&rsquo;\u0153strog\u00e8nes (ER-\u03b1 et ER-\u03b2) sont exprim\u00e9s dans de nombreux tissus\u00a0: paroi vasculaire, os, enc\u00e9phale et appareil urog\u00e9nital. Le d\u00e9ficit hormonal provoque des troubles v\u00e9g\u00e9tatifs syst\u00e9miques (bouff\u00e9es de chaleur) et des changements atrophiques localis\u00e9s. <\/p>\n\n<p>En gyn\u00e9cologie, un <strong>traitement local (vaginal)<\/strong> par de faibles doses d&rsquo;estriol est particuli\u00e8rement significatif. Le produit se lie s\u00e9lectivement aux r\u00e9cepteurs nucl\u00e9aires dans la couche basale de l&rsquo;\u00e9pith\u00e9lium vaginal, de l&rsquo;ur\u00e8tre et du trigone v\u00e9sical. Cela d\u00e9clenche la prolif\u00e9ration cellulaire, restaure la synth\u00e8se de collag\u00e8ne et d&rsquo;\u00e9lastine dans la sous-muqueuse, am\u00e9liore la vascularisation et stimule l&rsquo;accumulation de glycog\u00e8ne intracellulaire.<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x43A;&#x43B;&#x438;&#x43D;&#x438;&#x447;&#x435;&#x441;&#x43A;&#x43E;&#x435;-&#x437;&#x43D;&#x430;&#x447;&#x435;&#x43D;&#x438;&#x435;\"><strong>Importance clinique<\/strong><\/h2>\n\n<p>La th\u00e9rapie locale avec des \u0153strog\u00e8nes est l&rsquo;unique standard d&rsquo;or prouv\u00e9 pour le traitement du syndrome g\u00e9nito-urinaire de la m\u00e9nopause (<strong>vaginite atrophique<\/strong>). Elle r\u00e9tablit l&rsquo;\u00e9paisseur et l&rsquo;\u00e9lasticit\u00e9 de la muqueuse, normalise le pH et la population de lactobacilles, \u00e9liminant ainsi les sympt\u00f4mes de s\u00e9cheresse, de br\u00fblure, de dyspareunie et de cystites post-co\u00eftales r\u00e9currentes. Contrairement \u00e0 la THS syst\u00e9mique, les formes locales sont s\u00fbres, ne sont pratiquement pas absorb\u00e9es dans la circulation syst\u00e9mique et n&rsquo;augmentent pas le risque de cancer du sein ou de thromboembolies veineuses.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Le traitement hormonal substitutif (THS) est une strat\u00e9gie de correction pharmacologique des \u00e9tats d\u00e9ficients en \u0153strog\u00e8nes chez les femmes en p\u00e9ri- et postm\u00e9nopause. <\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-3928","glossary_item","type-glossary_item","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.0 (Yoast SEO v26.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Traitement hormonal substitutif : d\u00e9finition m\u00e9dicale et description | Voka Wiki<\/title>\n<meta name=\"description\" content=\"Le traitement hormonal substitutif (THS) 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