{"id":3448,"date":"2026-02-26T16:53:47","date_gmt":"2026-02-26T13:53:47","guid":{"rendered":"https:\/\/wiki.voka.io\/glossary\/reaction-de-jarisch-herxheimer\/"},"modified":"2026-02-26T16:53:52","modified_gmt":"2026-02-26T13:53:52","slug":"reaction-de-jarisch-herxheimer","status":"publish","type":"glossary_item","link":"https:\/\/wiki.voka.io\/fr\/glossaire\/reaction-de-jarisch-herxheimer\/","title":{"rendered":"La r\u00e9action de Jarisch-Herxheimer"},"content":{"rendered":"\n<p>La r\u00e9action de Jarisch-Gerxheimer (d&rsquo;apr\u00e8s les noms des dermatologues autrichien et allemand qui ont d\u00e9crit le ph\u00e9nom\u00e8ne) est une r\u00e9action immunitaire syst\u00e9mique transitoire de l&rsquo;organisme qui se d\u00e9veloppe dans les 24 heures suivant l&rsquo;instauration d&rsquo;une antibioth\u00e9rapie sp\u00e9cifique pour les infections \u00e0 spiroch\u00e8tes (syphilis, borr\u00e9liose, leptospirose).<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x44D;&#x442;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;-&#x438;-&#x43F;&#x430;&#x442;&#x43E;&#x444;&#x438;&#x437;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;\"><strong>\u00c9tiologie et physiopathologie<\/strong><\/h2>\n\n<p>La pathog\u00e9nie de la r\u00e9action n&rsquo;est pas allergique (il ne s&rsquo;agit pas d&rsquo;une anaphylaxie \u00e0 la p\u00e9nicilline). Elle est due \u00e0 une bact\u00e9riolyse (destruction) rapide des spiroch\u00e8tes sous l&rsquo;action de l&rsquo;antibiotique. Lorsque les bact\u00e9ries meurent en masse, des endotoxines, des lipoprot\u00e9ines et des fragments d&rsquo;ADN sont lib\u00e9r\u00e9s imm\u00e9diatement dans la circulation sanguine. Cela provoque une r\u00e9ponse immunitaire syst\u00e9mique &#8211; une \u00ab\u00a0temp\u00eate de cytokines\u00a0\u00bb avec une forte augmentation du niveau du facteur de n\u00e9crose tumorale (TNF-\u03b1), des interleukines IL-6 et IL-8.   <\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x43A;&#x43B;&#x438;&#x43D;&#x438;&#x447;&#x435;&#x441;&#x43A;&#x43E;&#x435;-&#x437;&#x43D;&#x430;&#x447;&#x435;&#x43D;&#x438;&#x435;\"><strong>Signification clinique<\/strong><\/h2>\n\n<p>Le tableau clinique se d\u00e9veloppe 2 \u00e0 8 heures apr\u00e8s la premi\u00e8re injection et ressemble \u00e0 un syndrome grippal : frissons soudains, \u00e9l\u00e9vation de la temp\u00e9rature corporelle \u00e0 39-40\u00b0C, maux de t\u00eate, myalgies, tachycardie et hypotension transitoire. La <strong>syphilis<\/strong> se caract\u00e9rise par une aggravation temporaire (brillance, gonflement) des \u00e9ruptions cutan\u00e9es et une infiltration accrue dans la zone du chancre primaire ou de la <strong>vaginite syphilitique<\/strong>. Cet \u00e9tat dispara\u00eet de lui-m\u00eame en l&rsquo;espace d&rsquo;un jour et constitue une confirmation indirecte de l&rsquo;efficacit\u00e9 du traitement.  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>La r\u00e9action de Jarisch-Gerxheimer (d&rsquo;apr\u00e8s les noms des dermatologues autrichien et allemand qui ont d\u00e9crit le ph\u00e9nom\u00e8ne) est une r\u00e9action immunitaire syst\u00e9mique transitoire de l&rsquo;organisme qui se d\u00e9veloppe dans les 24 heures suivant l&rsquo;instauration d&rsquo;une antibioth\u00e9rapie sp\u00e9cifique pour les infections \u00e0 spiroch\u00e8tes (syphilis, borr\u00e9liose, leptospirose).<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-3448","glossary_item","type-glossary_item","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.0 (Yoast SEO v26.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>La r\u00e9action de 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