{"id":8236,"date":"2026-02-26T16:53:00","date_gmt":"2026-02-26T13:53:00","guid":{"rendered":"https:\/\/wiki.voka.io\/diseases\/uncategorized\/14-jour-du-developpement-embryonnaire\/"},"modified":"2026-09-17T15:55:22","modified_gmt":"2026-09-17T12:55:22","slug":"14-jour-du-developpement-embryonnaire","status":"publish","type":"diseases_post","link":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/","title":{"rendered":"2e semaine du d\u00e9veloppement embryonnaire&#160;: structure, particularit\u00e9s morphog\u00e9n\u00e9tiques et importance clinico-anatomique"},"content":{"rendered":"<p><?xml encoding=\"UTF-8\" ?><\/p>\n<p class=\"wp-block-paragraph\">Le quatorzi\u00e8me jour du d\u00e9veloppement post-f\u00e9condation chez l\u2019\u00eatre humain repr\u00e9sente l\u2019une des \u00e9tapes les plus importantes de l\u2019embryogen\u00e8se pr\u00e9coce. Cette p\u00e9riode marque le d\u00e9but de la gastrulation, au cours de laquelle les trois feuillets embryonnaires \u2013 l\u2019ectoderme, le m\u00e9soderme et l\u2019endoderme \u2013 se forment \u00e0 partir du disque embryonnaire didermique. <\/p>\n<p class=\"wp-block-paragraph\">Il s\u2019agit d\u2019une \u00e9tape de transition entre l\u2019implantation et la gastrulation active. \u00c0 ce stade commence l\u2019interaction entre l\u2019embryon et l\u2019organisme maternel \u00e0 travers les lacunes du syncytiotrophoblaste. <\/p>\n<p class=\"wp-block-paragraph\">Simultan\u00e9ment, les principaux axes corporels se mettent en place, jetant les bases de l\u2019organisation du futur organisme\u00a0: <\/p>\n<ul class=\"wp-block-list\">\n<li>craniocaudal\u00a0; <\/li>\n<li>dorsoventral\u00a0; <\/li>\n<li>gauche-droite. <\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">Parall\u00e8lement \u00e0 ces processus se poursuit la formation des structures extra-embryonnaires, indispensables aux \u00e9changes normaux entre l\u2019embryon et l\u2019organisme maternel.<\/p>\n<h2 class=\"wp-block-heading\" id=\"morphologie-de-l-embryon-au-14e-jour\"><strong>Morphologie de l\u2019embryon au 14e jour<\/strong><\/h2>\n<p class=\"wp-block-paragraph\">\u00c0 ce stade, le disque embryonnaire mesure environ 1,5 \u00e0 2\u00a0mm. Malgr\u00e9 sa petite taille, il conserve sa structure didermique mais entre d\u00e9j\u00e0 activement dans une phase de restructuration. <\/p>\n<h3 class=\"wp-block-heading\" id=\"epiblaste\"><strong>\u00c9piblaste<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">La couche sup\u00e9rieure est constitu\u00e9e de l\u2019\u00e9piblaste\u00a0: de hautes cellules cylindriques pr\u00e9sentant une polarit\u00e9 apicalo-basale marqu\u00e9e et une activit\u00e9 mitotique \u00e9lev\u00e9e. L\u2019\u00e9piblaste est \u00e0 l\u2019origine de tous les tissus embryonnaires et forme simultan\u00e9ment la paroi de la cavit\u00e9 amniotique. <\/p>\n<p class=\"wp-block-paragraph\">Ses cellules \u00e9tablissent de solides jonctions intercellulaires gr\u00e2ce \u00e0 l\u2019expression des E-cadh\u00e9rines, mais ces liaisons s\u2019affaiblissent progressivement au niveau de l\u2019extr\u00e9mit\u00e9 caudale, pr\u00e9parant ainsi l\u2019\u00e9piblaste \u00e0 la migration. <\/p>\n<h3 class=\"wp-block-heading\" id=\"hypoblast\"><strong>Hypoblast<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">La couche inf\u00e9rieure du disque embryonnaire est repr\u00e9sent\u00e9e par l\u2019hypoblaste, compos\u00e9 de cellules aplaties formant une fine lame. Les cellules de l\u2019hypoblaste ne participent pas directement \u00e0 la formation des tissus embryonnaires, mais assurent le d\u00e9veloppement de l\u2019endoderme extra-embryonnaire et la formation de la v\u00e9sicule vitelline. <\/p>\n<p class=\"wp-block-paragraph\">Elles s\u00e9cr\u00e8tent \u00e9galement des mol\u00e9cules de signalisation\u00a0\u2013 <em>LEFTY1<\/em>, <em>Cer1<\/em> et <em>DKK1<\/em>, qui inhibent l\u2019expression de <em>WNT<\/em> et de <em>NODAL<\/em> dans la r\u00e9gion cr\u00e2niale. Cela permet d\u2019\u00e9viter une m\u00e9sodermalisation excessive et favorise le bon d\u00e9veloppement des structures ant\u00e9rieures.<\/p>\n<h3 class=\"wp-block-heading\" id=\"formation-de-la-ligne-primitive\"><strong>Formation de la ligne primitive<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">\u00c0 l\u2019extr\u00e9mit\u00e9 caudale du disque se forme la ligne primitive\u00a0: un \u00e9paississement de l\u2019\u00e9piblaste qui constitue le premier signe morphologique du d\u00e9but de la gastrulation et d\u00e9termine l\u2019axe craniocaudal de l\u2019embryon. <\/p>\n<p class=\"wp-block-paragraph\">Les cellules de la ligne primitive perdent leur polarit\u00e9 apicalo-basale, r\u00e9organisent leur cytosquelette sous le contr\u00f4le des <em>Rho-GTP<\/em>ases et acqui\u00e8rent des capacit\u00e9s migratoires. <\/p>\n<p class=\"wp-block-paragraph\">Dans la partie cr\u00e2niale de la ligne primitive appara\u00eet le n\u0153ud primitif (ou n\u0153ud de Hensen), qui agit comme un centre organisateur. Ses cellules s\u00e9cr\u00e8tent <em>NODAL<\/em>, <em>FGF8<\/em> et <em>WNT3A<\/em>, activant ainsi les processus de transition \u00e9pith\u00e9lio-m\u00e9senchymateuse et induisant la migration active des cellules \u00e9piblastiques vers l\u2019int\u00e9rieur du disque.<\/p>\n<h3 class=\"wp-block-heading\" id=\"formation-des-feuillets-embryonnaires\"><strong>Formation des feuillets embryonnaires<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">\u00c0 partir du 14e jour, on observe une migration des cellules \u00e9piblastiques, strictement ordonn\u00e9e. <\/p>\n<ol class=\"wp-block-list\">\n<li>La premi\u00e8re vague de cellules refoule l\u2019hypoblaste et forme l\u2019endoderme d\u00e9finitif, feuillet embryonnaire \u00e0 l\u2019origine de l\u2019\u00e9pith\u00e9lium du tube digestif et du syst\u00e8me respiratoire. <\/li>\n<li>Les vagues suivantes forment le m\u00e9soderme, intercal\u00e9 entre l\u2019\u00e9piblaste et l\u2019endoderme, qui donnera ensuite naissance aux muscles, aux vaisseaux, aux os, aux reins et au c\u0153ur.<\/li>\n<li>Les cellules qui restent \u00e0 la surface forment l\u2019ectoderme, \u00e0 partir duquel se d\u00e9velopperont le syst\u00e8me nerveux, les organes sensoriels et l\u2019\u00e9piderme. <\/li>\n<\/ol>\n<p class=\"wp-block-paragraph\">C\u2019est donc \u00e0 ce stade que se produit la diff\u00e9renciation finale des trois feuillets embryonnaires\u00a0\u2013 ectoderme, m\u00e9soderme et endoderme\u00a0\u2013 qui constitue le fondement de l\u2019organogen\u00e8se ult\u00e9rieure.<\/p>\n<h3 class=\"wp-block-heading\" id=\"etablissement-des-axes-spatiaux\"><strong>\u00c9tablissement des axes spatiaux<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">Au niveau de la r\u00e9gion cr\u00e2niale du disque se forme la plaque pr\u00e9chordale\u00a0\u2013 un \u00e9paississement local des cellules m\u00e9sodermiques qui sert de marqueur pr\u00e9coce de la membrane oropharyng\u00e9e et de rep\u00e8re important pour l\u2019extr\u00e9mit\u00e9 cr\u00e2niale de l\u2019embryon. <\/p>\n<p class=\"wp-block-paragraph\">Parall\u00e8lement \u00e0 ces processus morphog\u00e9n\u00e9tiques, les axes spatiaux de l\u2019embryon se mettent en place. <\/p>\n<ul class=\"wp-block-list\">\n<li><strong>L\u2019axe craniocaudal<\/strong> est d\u00e9termin\u00e9 par la formation de la ligne primitive et de la plaque pr\u00e9chordale\u00a0; <\/li>\n<li><strong>L\u2019axe dorsoventral <\/strong>est \u00e9tabli par la diff\u00e9rence entre l\u2019\u00e9piblaste, situ\u00e9 dorsalement, et l\u2019hypoblaste, qui occupe une position ventrale\u00a0; <\/li>\n<li><strong>L\u2019asym\u00e9trie gauche-droite<\/strong> est due \u00e0 l\u2019activit\u00e9 du n\u0153ud de Hensen\u00a0: les cils de ses cellules cr\u00e9ent un flux de liquide orient\u00e9, tandis que l\u2019expression locale des g\u00e8nes <em>NODAL<\/em> et <em>LEFTY2<\/em> active le facteur de transcription <em>PITX2<\/em> exclusivement \u00e0 gauche, induisant le programme d\u2019organogen\u00e8se du c\u00f4t\u00e9 gauche.<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">Ci-dessous figure un sch\u00e9ma d\u00e9taill\u00e9 de la structure\u00a0:<\/p>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/3d-diagram-with-numbered-structures-and-legend.webp\" alt=\"Embryon au 14e jour de d\u00e9veloppement (sch\u00e9ma 3D avec num\u00e9rotation des structures)\"><figcaption class=\"wp-element-caption\">Embryon au 14e jour de d\u00e9veloppement (sch\u00e9ma 3D avec num\u00e9rotation des structures)<\/figcaption><\/figure>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/embryo-development-day-14-gastrulation-and-disc-formation.webp\" alt=\"Embryon au 14e jour de d\u00e9veloppement\"><figcaption class=\"wp-element-caption\">Embryon au 14e jour de d\u00e9veloppement\u00a0\u2013 <a href=\"https:\/\/catalog.voka.io\/fr\/models\/bca0620c-bc76-40ec-be54-3271bc217411\/53623f0b-89eb-4fbb-9c0d-655c1e0eb084\/fd22b7cd-b13a-409e-ae67-f9cb3088c492\/a11b0c61-886b-4be3-bcd6-c584e88b385c\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">mod\u00e8le\u00a03D<\/a><\/figcaption><\/figure>\n<ol class=\"wp-block-list\">\n<li><strong>Amnios (sph\u00e8re bleue)\u00a0:<\/strong>\n<ul class=\"wp-block-list\">\n<li>D\u00e9rive de l\u2019\u00e9piblaste\u00a0;<\/li>\n<li>Forme la cavit\u00e9 amniotique, remplie de liquide amniotique\u00a0;<\/li>\n<li>Fonction : protection de l\u2019embryon contre les dommages m\u00e9caniques et maintien d\u2019un environnement constant.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/amniotic-cavity-structure.webp\" alt=\"cavit\u00e9 amniotique\"><figcaption class=\"wp-element-caption\">Cavit\u00e9 amniotique\u00a0\u2013 <a href=\"https:\/\/catalog.voka.io\/fr\/models\/bca0620c-bc76-40ec-be54-3271bc217411\/53623f0b-89eb-4fbb-9c0d-655c1e0eb084\/fd22b7cd-b13a-409e-ae67-f9cb3088c492\/a11b0c61-886b-4be3-bcd6-c584e88b385c\">mod\u00e8le\u00a03D<\/a><\/figcaption><\/figure>\n<ol start=\"2\" class=\"wp-block-list\">\n<li><strong>V\u00e9sicule vitelline (sph\u00e8re jaune en bas)\u00a0:<\/strong>\n<ul class=\"wp-block-list\">\n<li>D\u00e9rive de l\u2019hypoblaste\u00a0;<\/li>\n<li>\u00c0 ce stade, constitue la v\u00e9sicule vitelline secondaire\u00a0;<\/li>\n<li>Participe \u00e0 l\u2019h\u00e9matopo\u00ef\u00e8se primitive et \u00e0 la mise en place des \u00e9bauches du syst\u00e8me reproducteur.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/yolk-sac-development.webp\" alt=\"v\u00e9sicule ombilicale\"><figcaption class=\"wp-element-caption\">V\u00e9sicule vitelline\u00a0\u2013 <a href=\"https:\/\/catalog.voka.io\/fr\/models\/bca0620c-bc76-40ec-be54-3271bc217411\/53623f0b-89eb-4fbb-9c0d-655c1e0eb084\/fd22b7cd-b13a-409e-ae67-f9cb3088c492\/a11b0c61-886b-4be3-bcd6-c584e88b385c\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">mod\u00e8le\u00a03D<\/a><\/figcaption><\/figure>\n<ol start=\"3\" class=\"wp-block-list\">\n<li><strong>Disque embryonnaire (plaque rose-rouge)\u00a0:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Didermique\u00a0: \u00e9piblaste (couche sup\u00e9rieure) et hypoblaste (couche inf\u00e9rieure)\u00a0;<\/li>\n<li>Au 14e jour commence la gastrulation\u00a0: la formation des trois feuillets embryonnaires.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/embryonic-disc-structure.webp\" alt=\"Disque embryonnaire\"><figcaption class=\"wp-element-caption\">Disque embryonnaire<em> \u2013 <\/em><a href=\"https:\/\/catalog.voka.io\/fr\/models\/bca0620c-bc76-40ec-be54-3271bc217411\/53623f0b-89eb-4fbb-9c0d-655c1e0eb084\/fd22b7cd-b13a-409e-ae67-f9cb3088c492\/a11b0c61-886b-4be3-bcd6-c584e88b385c\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">mod\u00e8le\u00a03D<\/a><\/figcaption><\/figure>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/differentiation-of-epiblast-and-hypoblast-layers.webp\" alt=\"\u00c9piblaste et hypoblaste\"><figcaption class=\"wp-element-caption\">\u00c9piblaste et hypoblaste<em>\u00a0\u2013 <\/em><a href=\"https:\/\/catalog.voka.io\/fr\/models\/bca0620c-bc76-40ec-be54-3271bc217411\/53623f0b-89eb-4fbb-9c0d-655c1e0eb084\/fd22b7cd-b13a-409e-ae67-f9cb3088c492\/a11b0c61-886b-4be3-bcd6-c584e88b385c\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">mod\u00e8le\u00a03D<\/a><\/figcaption><\/figure>\n<ol start=\"4\" class=\"wp-block-list\">\n<li><strong>Ligne primitive (bande rouge)\u00a0:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Appara\u00eet \u00e0 l\u2019extr\u00e9mit\u00e9 caudale du disque embryonnaire\u00a0;<\/li>\n<li>D\u00e9termine l\u2019axe t\u00eate-queue (orientation craniocaudale)\u00a0;<\/li>\n<li>Les cellules de l\u2019\u00e9piblaste y migrent pour former le m\u00e9soderme et l\u2019endoderme.<\/li>\n<\/ul>\n<\/li>\n<li><strong>N\u0153ud de Hensen (point rouge fonc\u00e9 \u00e0 l\u2019extr\u00e9mit\u00e9 ant\u00e9rieure de la ligne)\u00a0:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Organisateur de l\u2019axe embryonnaire\u00a0;<\/li>\n<li>R\u00e9gule la migration cellulaire, la mise en place de la notochorde et la sym\u00e9trie corporelle.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Migration cellulaire (fl\u00e8ches)\u00a0:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Fl\u00e8ches vertes \u2192 Endoderme<br \/>Les cellules remplacent l\u2019hypoblaste et forment le feuillet interne, \u00e0 l\u2019origine des syst\u00e8mes respiratoire et digestif.<\/li>\n<li>Fl\u00e8ches bleues \u2192 M\u00e9soderme<br \/>Les cellules se situent entre l\u2019ectoderme et l\u2019endoderme, formant les muscles squelettiques, les os, le tissu conjonctif, les vaisseaux et les reins.<\/li>\n<li>Fl\u00e8ches violettes \u2192 Ectoderme<br \/>Les cellules restant dans l\u2019\u00e9piblaste constituent le feuillet externe, \u00e0 partir duquel se d\u00e9veloppent la peau et le syst\u00e8me nerveux.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Axes (annotations autour du sch\u00e9ma) :<\/strong>\n<ul class=\"wp-block-list\">\n<li>Craniocaudal (t\u00eate \u2194 queue)\u00a0;<\/li>\n<li>Gauche-droite (future sym\u00e9trie corporelle)\u00a0;<\/li>\n<li>Dorsoventral (dos \u2194 ventre).<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\" id=\"structures-extra-embryonnaires\"><strong>Structures extra-embryonnaires <\/strong><\/h2>\n<p class=\"wp-block-paragraph\">\u00c0 ce stade, le d\u00e9veloppement de l\u2019embryon est \u00e9troitement li\u00e9 \u00e0 la formation des structures extra-embryonnaires qui assurent sa nutrition, sa protection et la formation du futur placenta.<\/p>\n<h3 class=\"wp-block-heading\" id=\"amnios\"><strong>Amnios<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">L\u2019amnios se forme \u00e0 partir des amnioblastes, d\u00e9riv\u00e9s de l\u2019\u00e9piblaste. Ces cellules constituent une mince membrane tapissant la cavit\u00e9 amniotique, situ\u00e9e au-dessus de l\u2019\u00e9piblaste. La cavit\u00e9 amniotique s\u2019agrandit progressivement et se remplit de liquide amniotique. D\u00e8s ce stade, l\u2019amnios commence \u00e0 jouer son r\u00f4le protecteur en cr\u00e9ant un environnement optimal pour le d\u00e9veloppement embryonnaire.<\/p>\n<h3 class=\"wp-block-heading\" id=\"vesicule-ombilicale\"><strong>V\u00e9sicule ombilicale<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">Au 14e jour, la v\u00e9sicule vitelline prend l\u2019aspect d\u2019une v\u00e9sicule secondaire (d\u00e9finitive). Sa paroi est tapiss\u00e9e par les cellules de l\u2019hypoblaste et de l\u2019endoderme extra-embryonnaire. C\u2019est ensuite dans la v\u00e9sicule vitelline que se mettent en place les foyers d\u2019h\u00e9matopo\u00ef\u00e8se primitive et que se forment les \u00e9bauches des cellules germinales. <\/p>\n<p class=\"wp-block-paragraph\">Bien que chez l\u2019humain la v\u00e9sicule vitelline ne participe pas \u00e0 la nutrition de l\u2019embryon, elle est importante comme source de lign\u00e9es cellulaires et comme organe h\u00e9matopo\u00ef\u00e9tique temporaire.<\/p>\n<h3 class=\"wp-block-heading\" id=\"chorion\"><strong>Chorion<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">Le chorion se forme \u00e0 partir des cellules du trophoblaste et du m\u00e9soderme extra-embryonnaire adjacent. \u00c0 ce stade, le chorion subit des modifications cl\u00e9s qui d\u00e9terminent la formation future du placenta. L\u2019implantation du trophoblaste dans l\u2019endom\u00e8tre s\u2019accompagne du d\u00e9veloppement du r\u00e9seau villositaire\u00a0: les villosit\u00e9s primaires se forment, constitu\u00e9es d\u2019un axe central de cytotrophoblaste recouvert par une couche de syncytiotrophoblaste.<\/p>\n<p class=\"wp-block-paragraph\">Au sein du syncytiotrophoblaste apparaissent des lacunes qui se remplissent progressivement de sang maternel. Ce processus marque le d\u00e9but de la mise en place des \u00e9changes materno-embryonnaires primitifs, premi\u00e8re forme de circulation placentaire.<\/p>\n<h3 class=\"wp-block-heading\" id=\"allantoide-ebauche-initiale\"><strong>Allanto\u00efde (\u00e9bauche initiale)<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">Bien que l\u2019allanto\u00efde commence \u00e0 se former un peu plus tard (vers le 16e\u00a0jour), la r\u00e9gion \u00e0 partir de laquelle elle d\u00e9rivera se met en place d\u00e8s ce stade dans la partie caudale du disque embryonnaire. L\u2019allanto\u00efde joue un r\u00f4le important dans la formation des vaisseaux sanguins placentaires et la mise en place de la vessie.<\/p>\n<h2 class=\"wp-block-heading\" id=\"stades-de-l-embryogenese-stades-carnegie\"><strong>Stades de l\u2019embryogen\u00e8se (stades Carnegie)<\/strong><\/h2>\n<p class=\"wp-block-paragraph\">En embryologie, le d\u00e9veloppement humain est g\u00e9n\u00e9ralement d\u00e9crit selon les stades de Carnegie (<em>Carnegie stages<\/em>), un syst\u00e8me de classification universel fond\u00e9 non pas sur l\u2019\u00e2ge de l\u2019embryon en jours, mais sur ses caract\u00e9ristiques morphologiques. Il existe au total 23\u00a0stades, qui couvrent la p\u00e9riode allant de la f\u00e9condation jusqu\u2019\u00e0 la fin de la 8e\u00a0semaine (56e\u00a0jour). <\/p>\n<p class=\"wp-block-paragraph\">\u00c0 ce stade, l\u2019embryon correspond au stade 6 de Carnegie. Cliniquement, il s\u2019agit de la p\u00e9riode o\u00f9 l\u2019embryon ne pr\u00e9sente pas encore d\u2019axes corporels clairement d\u00e9finis (t\u00eate-queue, dos-abdomen), mais o\u00f9 se mettent d\u00e9j\u00e0 en place les principales structures extra-embryonnaires indispensables \u00e0 sa croissance et \u00e0 son implantation. <\/p>\n<p class=\"wp-block-paragraph\">L\u2019\u00e9v\u00e9nement cl\u00e9 de ce stade est la mise en place des conditions n\u00e9cessaires \u00e0 la gastrulation, qui d\u00e9butera au stade suivant. Le stade\u00a06 de Carnegie se caract\u00e9rise par les particularit\u00e9s suivantes\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u00c2ge de l\u2019embryon\u00a0:<\/strong> environ 13 \u00e0 15\u00a0jours apr\u00e8s la f\u00e9condation\u00a0;<\/li>\n<li><strong>Taille de l\u2019embryon\u00a0:<\/strong> environ 0,1 \u00e0 0,2\u00a0mm\u00a0;<\/li>\n<li><strong>Caract\u00e9ristique\u00a0:<\/strong> stade du disque embryonnaire didermique (disque embryonnaire bilaminaire).<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">Les processus majeurs sont les suivants\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li>L\u2019embryon se pr\u00e9sente sous forme d\u2019un disque plat, constitu\u00e9 de l\u2019\u00e9piblaste et de l\u2019hypoblaste\u00a0;<\/li>\n<li>Au-dessus de l\u2019\u00e9piblaste se forme la cavit\u00e9 amniotique, tapiss\u00e9e par les amnioblastes\u00a0;<\/li>\n<li>Sous l\u2019hypoblaste se d\u00e9veloppe la v\u00e9sicule vitelline primaire (et puis secondaire).<br \/>Entre le cytotrophoblaste et la membrane exoc\u0153lomique appara\u00eet le m\u00e9soderme extra-embryonnaire, au sein duquel se forme bient\u00f4t la cavit\u00e9 c\u0153lomique extra-embryonnaire ;<\/li>\n<li>Le chorion, avec ses villosit\u00e9s primaires (cytotrophoblaste et syncytiotrophoblaste), commence \u00e0 se mettre en place.<\/li>\n<\/ul>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/embryonic-disc-with-amniotic-cavity-and-yolk-sac-spatial-structurepng\" alt=\"Disque embryonnaire avec cavit\u00e9 amniotique et v\u00e9sicule vitelline\"><figcaption class=\"wp-element-caption\">Disque embryonnaire avec cavit\u00e9 amniotique et v\u00e9sicule vitelline\u00a0\u2013 <a href=\"https:\/\/catalog.voka.io\/fr\/models\/bca0620c-bc76-40ec-be54-3271bc217411\/53623f0b-89eb-4fbb-9c0d-655c1e0eb084\/fd22b7cd-b13a-409e-ae67-f9cb3088c492\/a11b0c61-886b-4be3-bcd6-c584e88b385c\">mod\u00e8le\u00a03D<\/a><\/figcaption><\/figure>\n<p class=\"wp-block-paragraph\"><strong>Progression de l\u2019embryogen\u00e8se (stades 5 \u00e0 7 de Carnegie)<\/strong><\/p>\n<figure class=\"wp-block-table table-to-cards table-accents\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th class=\"has-text-align-center\" data-align=\"center\"><strong>Stade\u00a05 (jour 11\u201313)<\/strong><\/th>\n<th class=\"has-text-align-center\" data-align=\"center\"><strong>Stade\u00a06 (jour 13\u201315)<\/strong><\/th>\n<th class=\"has-text-align-center\" data-align=\"center\"><strong>Stade\u00a07 (jour 16\u201319)<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">Ach\u00e8vement de l\u2019implantation<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">V\u00e9sicule vitelline secondaire<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">Ligne primitive et n\u0153ud de Hensen<\/td>\n<\/tr>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">Disque didermique<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">Amnios<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">D\u00e9but de la gastrulation<\/td>\n<\/tr>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">cavit\u00e9 amniotique<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">Chorion avec villosit\u00e9s primaires<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">Processus notochordal<\/td>\n<\/tr>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">V\u00e9sicule vitelline primaire<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">Cavit\u00e9 c\u0153lomique extra-embryonnaire<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">Formation des 3 feuillets<\/td>\n<\/tr>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">Lacunes dans le syncytiotrophoblaste<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">Pr\u00e9paration \u00e0 la gastrulation<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">D\u00e9termination des axes corporels<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<div class=\"social-banner-block\">\n<div class=\"social-banner-content\">\n<p class=\"h5-title text-black\">Retrouvez d\u2019autres contenus scientifiquement exacts sur nos m\u00e9dias sociaux<\/p>\n<p><span class=\"social-banner-text text-grey\">Abonnez-vous et ne manquez pas les derni\u00e8res ressources<\/span><\/p>\n<div class=\"banner-icons-wrapper\"><a class=\"social-icon-link\" href=\"\" data-link=\"https:\/\/www.facebook.com\/VOKA3DAnatomyAndPathology\/\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/common\/Social%20Icons\/facebook.svg\" alt=\"social link\"><\/a><a class=\"social-icon-link\" href=\"\" data-link=\"https:\/\/www.instagram.com\/voka.io\/\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/common\/Social%20Icons\/insta.svg\" alt=\"social link\"><\/a><a class=\"social-icon-link\" href=\"\" data-link=\"https:\/\/www.linkedin.com\/company\/voka-io\/posts\/?feedView=all\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/common\/Social%20Icons\/linkedin.svg\" alt=\"social link\"><\/a><a class=\"social-icon-link\" href=\"\" data-link=\"https:\/\/www.youtube.com\/@vokaio\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/common\/Social%20Icons\/youtube.svg\" alt=\"social link\"><\/a><a class=\"social-icon-link\" href=\"\" data-link=\"https:\/\/www.pinterest.com\/voka3danatomyandpathology\/\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/common\/Social%20Icons\/pinterest.svg\" alt=\"social link\"><\/a><a class=\"social-icon-link\" href=\"\" data-link=\"https:\/\/www.tiktok.com\/@voka.io\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/common\/Social%20Icons\/tiktok.svg\" alt=\"social link\"><\/a><\/div>\n<\/div>\n<p><img decoding=\"async\" class=\"social-banner-image\" loading=\"lazy\" src=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/common\/social-media-banner-mobile-image.webp\" alt=\"Banner background\"><\/div>\n<h2 class=\"wp-block-heading\" id=\"regulation-moleculaire-de-la-gastrulation-et-des-axes-corporels\"><strong>R\u00e9gulation mol\u00e9culaire de la gastrulation et des axes corporels<\/strong><\/h2>\n<p class=\"wp-block-paragraph\">La formation de la ligne primitive et la diff\u00e9renciation de l\u2019embryon en trois feuillets sont contr\u00f4l\u00e9es par des cascades de signalisation complexes. <\/p>\n<h3 class=\"wp-block-heading\" id=\"role-central-de-nodal-famille-tgf\"><strong>R\u00f4le central de NODAL (famille TGF-\u03b2)<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">Le facteur <em>NODAL<\/em> constitue le r\u00e9gulateur cl\u00e9, indispensable pour\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li>l\u2019initiation de la migration des cellules de l\u2019\u00e9piblaste\u00a0;<\/li>\n<li>l\u2019induction de l\u2019endoderme\u00a0;<\/li>\n<li>l\u2019induction du m\u00e9soderme.<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">Son effet d\u00e9pend du niveau d\u2019expression\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li>expression \u00e9lev\u00e9e \u2192 formation de l\u2019endoderme\u00a0;<\/li>\n<li>expression plus faible \u2192 formation du m\u00e9soderme.<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">L\u2019activit\u00e9 spatiale de <em>NODAL<\/em> est strictement contr\u00f4l\u00e9e par ses antagonistes\u00a0\u2013 <em>LEFTY1, LEFTY2<\/em> et <em>CER1<\/em>, ce qui emp\u00eache une formation excessive de m\u00e9soderme.<\/p>\n<h3 class=\"wp-block-heading\" id=\"voie-de-signalisation-wnt-et-son-interaction-avec-bmp4\"><strong>Voie de signalisation WNT et son interaction avec BMP4<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">Les prot\u00e9ines <em>WNT3<\/em> et <em>WNT3A<\/em>\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li>activent l\u2019expression de <em>NODAL<\/em>\u00a0;<\/li>\n<li>amplifient les processus de formation du m\u00e9soderme.<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">L\u2019interaction de <em>WNT<\/em> avec <em>BMP4<\/em>\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li>stimule la formation de la ligne primitive\u00a0;<\/li>\n<li>favorise le d\u00e9veloppement du m\u00e9soderme lat\u00e9ral.<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">Cependant, un \u00e9quilibre strict est requis\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li><em>BMP4<\/em> stimule le m\u00e9soderme\u00a0;<\/li>\n<li>ses inhibiteurs (<em>CHORDIN, NOGGIN, FOLLISTATIN<\/em>) limitent son activit\u00e9 dans la r\u00e9gion dorsale\u00a0;<\/li>\n<li>l\u2019ensemble permet la formation du m\u00e9soderme axial et de la future notochorde.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\" id=\"regulation-de-la-migration-cellulaire-role-de-fgf8\"><strong>R\u00e9gulation de la migration cellulaire\u00a0: r\u00f4le de FGF8<\/strong><\/h3>\n<p class=\"wp-block-paragraph\">La prot\u00e9ine <em>FGF8<\/em>, s\u00e9cr\u00e9t\u00e9e par les cellules de la ligne primitive\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li>r\u00e9gule la migration des cellules de l\u2019\u00e9piblaste\u00a0;<\/li>\n<li>inhibe l\u2019expression de la E-cadh\u00e9rine\u00a0;<\/li>\n<li>diminue l\u2019adh\u00e9rence intercellulaire\u00a0;<\/li>\n<li>d\u00e9clenche la transition \u00e9pith\u00e9lio-m\u00e9senchymateuse.<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">Par cons\u00e9quent, les cellules de l\u2019\u00e9piblaste acqui\u00e8rent la capacit\u00e9 de migrer vers l\u2019int\u00e9rieur de l\u2019embryon.<\/p>\n<p class=\"wp-block-paragraph\">Parall\u00e8lement, les axes embryonnaires se mettent en place.<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>L\u2019axe craniocaudal<\/strong> s\u2019\u00e9tablit gr\u00e2ce \u00e0 l\u2019expression des inhibiteurs de <em>WNT<\/em> et de <em>BMP<\/em> (<em>CER1, DKK1, LEFTY1<\/em>) dans la r\u00e9gion cr\u00e2niale, ce qui emp\u00eache une m\u00e9sodermisation excessive et permet le d\u00e9veloppement des structures c\u00e9phaliques\u00a0;<\/li>\n<li><strong>L\u2019axe dorsoventral<\/strong> est d\u00e9termin\u00e9 par les gradients de <em>BMP<\/em> et de ses antagonistes (<em>CHORDIN, NOGGIN, FOLLISTATIN<\/em>). Une concentration \u00e9lev\u00e9e de BMP induit la formation des structures ventrales, tandis que son inhibition dans la r\u00e9gion dorsale fa\u00e7onne les structures dorsales\u00a0;<\/li>\n<li><strong>L\u2019asym\u00e9trie gauche-droite<\/strong> est initi\u00e9e dans la r\u00e9gion du n\u0153ud de Hensen. \u00c0 ce niveau sont exprim\u00e9es les prot\u00e9ines <em>NODAL<\/em> et <em>LEFTY2<\/em>, qui activent le facteur de transcription PITX2 uniquement du c\u00f4t\u00e9 gauche de l\u2019embryon. Il s\u2019agit du m\u00e9canisme cl\u00e9 d\u00e9terminant le positionnement correct du c\u0153ur, de l\u2019estomac et des autres organes asym\u00e9triques.<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">Des facteurs de transcription interviennent \u00e9galement dans ces processus\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li><em>BRACHYURY (T)<\/em> est indispensable \u00e0 la formation du m\u00e9soderme, notamment du m\u00e9soderme axial (notochorde)\u00a0;<\/li>\n<li><em>GOOSECOID<\/em> est exprim\u00e9 au niveau du n\u0153ud et r\u00e9gule la migration cellulaire, soutenant ainsi la formation des structures cr\u00e2niales\u00a0;<\/li>\n<li><em>OTX2, LIM1<\/em> et <em>HESX1<\/em> sont des facteurs cl\u00e9s du d\u00e9veloppement du cerveau ant\u00e9rieur et de la t\u00eate\u00a0;<\/li>\n<li>Les <em>g\u00e8nes HOX<\/em> conf\u00e8rent au m\u00e9soderme une identit\u00e9 segmentaire le long de l\u2019axe craniocaudal, d\u00e9terminant ainsi le positionnement des futurs somites et organes internes.<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">Parall\u00e8lement, le d\u00e9veloppement des structures extra-embryonnaires se poursuit. Le syncytiotrophoblaste s\u00e9cr\u00e8te la gonadotrophine chorionique humaine (<em>hCG<\/em>, cod\u00e9e par les g\u00e8nes de la famille <em>CGB<\/em>), qui maintient la fonction du corps jaune et assure la s\u00e9cr\u00e9tion de progest\u00e9rone. <\/p>\n<p class=\"wp-block-paragraph\">Une implantation r\u00e9ussie et le d\u00e9veloppement placentaire n\u00e9cessitent l\u2019action des m\u00e9talloprot\u00e9inases (<em>MMP2<\/em> et <em>MMP9<\/em>), qui d\u00e9gradent la matrice extracellulaire de l\u2019endom\u00e8tre et permettent l\u2019invasion trophoblastique. Les facteurs <em>VEGF<\/em> et <em>PGF<\/em> stimulent la croissance du r\u00e9seau vasculaire du chorion pour cr\u00e9er les conditions n\u00e9cessaires aux \u00e9changes materno-embryonnaires. <\/p>\n<p class=\"wp-block-paragraph\">Enfin, l\u2019expression de <em>HLA-G<\/em> assure la tol\u00e9rance immunologique maternelle en bloquant la destruction du trophoblaste par les cellules NK et en pr\u00e9venant tout conflit immunitaire.<\/p>\n<p class=\"wp-block-paragraph\">Ainsi, le d\u00e9veloppement \u00e0 ce stade peut \u00eatre repr\u00e9sent\u00e9 comme l\u2019interaction de deux syst\u00e8mes\u00a0:<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>Les signaux embryonnaires<\/strong> (<em>NODAL, WNT, BMP, FGF<\/em> et leurs antagonistes) d\u00e9terminent l\u2019organisation spatio-temporelle de la gastrulation et la formation des axes\u00a0;<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\"><strong>Les signaux extra-embryonnaires<\/strong> (<em>CGB, MMP, VEGF, HLA-G<\/em>) assurent la nutrition, l\u2019invasion et la protection immunitaire de l\u2019embryon.<\/p>\n<div>\n<h2 class=\"faq-title h2-article\" id=\"faq\">FAQ<\/h2>\n<div class=\"faq-section\">\n<div class=\"faq-item faq-answer-hidden\">\n<div class=\"question-block\">\n<div class=\"faq-question\">\n<p class=\" text-black h5-title\">1. Est-il possible de visualiser l\u2019embryon \u00e0 l\u2019\u00e9chographie \u00e0 deux semaines de d\u00e9veloppement\u00a0?<\/p>\n<\/div>\n<div class=\"faq-answer text-main-text-color main-text-medium\">\u00c0 deux semaines de d\u00e9veloppement embryonnaire (ce qui correspond \u00e0 4\u00a0semaines d\u2019am\u00e9norrh\u00e9e), la visualisation directe de l\u2019embryon par \u00e9chographie n\u2019est pas encore possible, car il ne mesure qu\u2019environ 1,5 millim\u00e8tre. Cependant, les appareils d\u2019\u00e9chographie endovaginale modernes permettent d\u00e9j\u00e0 de d\u00e9tecter le sac gestationnel, fermement implant\u00e9 dans la cavit\u00e9 ut\u00e9rine, qui appara\u00eet \u00e0 l\u2019\u00e9cran sous forme d\u2019une petite formation an\u00e9chog\u00e8ne (sombre) d\u2019environ 2 \u00e0 3\u00a0millim\u00e8tres de diam\u00e8tre.<\/div>\n<\/div>\n<div class=\"expand-button-wrapper\"><button class=\"text-accent expand-button\">+<\/button><\/div>\n<\/div>\n<div class=\"faq-item faq-answer-hidden\">\n<div class=\"question-block\">\n<div class=\"faq-question\">\n<p class=\" text-black h5-title\">2. O\u00f9 se trouve l\u2019embryon \u00e0 deux semaines de d\u00e9veloppement\u00a0?<\/p>\n<\/div>\n<div class=\"faq-answer text-main-text-color main-text-medium\">\u00c0 la fin du quatorzi\u00e8me jour de la p\u00e9riode post-conceptionnelle, l\u2019embryon est d\u00e9j\u00e0 enti\u00e8rement implant\u00e9 dans l\u2019endom\u00e8tre, la couche fonctionnelle de la muqueuse ut\u00e9rine. Le processus d\u2019implantation s\u2019ach\u00e8ve \u00e0 ce stade, tandis que la couche cellulaire externe (le trophoblaste) envahit activement les tissus maternels, formant les villosit\u00e9s choriales primaires ainsi que des lacunes qui se remplissent de sang maternel pour assurer les \u00e9changes placentaires pr\u00e9coces.<\/div>\n<\/div>\n<div class=\"expand-button-wrapper\"><button class=\"text-accent expand-button\">+<\/button><\/div>\n<\/div>\n<div class=\"faq-item faq-answer-hidden\">\n<div class=\"question-block\">\n<div class=\"faq-question\">\n<p class=\" text-black h5-title\">3. Quelle est la taille exacte de l\u2019embryon au 14e jour\u00a0?<\/p>\n<\/div>\n<div class=\"faq-answer text-main-text-color main-text-medium\">Au 14e jour de l\u2019embryogen\u00e8se (correspondant au stade\u00a06 de Carnegie), le disque embryonnaire ne mesure que 1,5 \u00e0 2\u00a0millim\u00e8tres de long, et l\u2019embryon lui-m\u00eame se pr\u00e9sente sous forme d\u2019une minuscule plaque didermique. Malgr\u00e9 ses dimensions microscopiques, des processus morphog\u00e9n\u00e9tiques complexes se d\u00e9roulent d\u00e9j\u00e0 au sein de ce disque cellulaire\u00a0: se forment la cavit\u00e9 amniotique et la v\u00e9sicule vitelline secondaire, posant ainsi les bases du d\u00e9veloppement futur de tous les syst\u00e8mes de l\u2019organisme.<\/div>\n<\/div>\n<div class=\"expand-button-wrapper\"><button class=\"text-accent expand-button\">+<\/button><\/div>\n<\/div>\n<div class=\"faq-item faq-answer-hidden\">\n<div class=\"question-block\">\n<div class=\"faq-question\">\n<p class=\" text-black h5-title\">4. Quels sont les sympt\u00f4mes ressentis par la femme \u00e0 la deuxi\u00e8me semaine d\u2019embryogen\u00e8se\u00a0?<\/p>\n<\/div>\n<div class=\"faq-answer text-main-text-color main-text-medium\">Durant cette p\u00e9riode, qui co\u00efncide avec le d\u00e9but du retard des r\u00e8gles, la femme peut percevoir les premiers signes de grossesse, dus \u00e0 l\u2019augmentation du taux de gonadotrophine chorionique humaine (hCG). Les sympt\u00f4mes caract\u00e9ristiques incluent une somnolence accrue, une sensibilit\u00e9 ou un gonflement des seins, une sensation de pesanteur dans le bas-ventre, ainsi que de l\u00e9gers saignements li\u00e9s \u00e0 l\u2019implantation du trophoblaste dans la paroi ut\u00e9rine hypervascularis\u00e9e.<\/div>\n<\/div>\n<div class=\"expand-button-wrapper\"><button class=\"text-accent expand-button\">+<\/button><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"sources-list-block sources-list-hidden\" id=\"references\">\n<div class=\"sources-list-content\">\n<div class=\"sources-list-title\">\n<p class=\"small-text-bold text-black sources-list-title-text\">R\u00e9f\u00e9rences<\/p>\n<div class=\"sources-expand-button-wrapper-mobile\">\n<div class=\"sources-expand-button\"><svg width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M8 12L16 20L24 12\" stroke=\"#8C9AAB\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/svg><\/div>\n<\/div>\n<\/div>\n<div class=\"sources-list-items\">\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">1.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>VOKA 3D Anatomy & Pathology \u2013 Atlas 3D complet d\u2019anatomie et de pathologie [Internet]. VOKA 3D Anatomy & Pathology (VOKA 3D Anatomie et Pathologie). <\/cite><\/p>\n<p><span class=\"small-text-medium text-grey\">Disponible depuis\u00a0: https:\/\/catalog.voka.io\/<\/span><\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">2.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Sadler TW. Langman\u2019s Medical Embryology [Embryologie m\u00e9dicale de Langman]. 14th ed. Philadelphia: Wolters Kluwer; 2019.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">3.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Moore KL, Persaud TVN, Torchia MG. The Developing Human: Clinically Oriented Embryology [L\u2019\u00eatre humain en d\u00e9veloppement\u00a0: embryologie clinique]. 11th ed. Philadelphia: Elsevier; 2020.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">4.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Schoenwolf GC, Bleyl SB, Brauer PR, Francis-West PH. Larsen\u2019s Human Embryology [Embryologie humaine de Larsen]. 6th ed. Philadelphia: Elsevier; 2021.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">5.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Deglincerti A, Croft GF, Pietila LN, et al. Self-organization of the in vitro attached human embryo [Auto-organisation de l\u2019embryon humain implant\u00e9 in vitro]. Nature. 2016;533(7602):251-254.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">6.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Shahbazi MN, Jedrusik A, Vuoristo S, et al. Self-organization of the human embryo in the absence of maternal tissues [Auto-organisation de l\u2019embryon humain en l\u2019absence de tissus maternels]. Nat Cell Biol. 2016;18(6):700-708.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">7.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Xiang L, Yin Y, Zheng Y, et al. A developmental landscape of 3D-cultured human pre-gastrulation embryos [Panorama du d\u00e9veloppement des embryons humains en culture\u00a03D au stade de pr\u00e9-gastrulation]. Nature. 2020;577(7791):537-542.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">8.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Tyser RCV, Mahammadov E, Nakanoh S, et al. Single-cell transcriptomic characterization of a gastrulating human embryo [Caract\u00e9risation transcriptomique d\u2019un embryon humain en cours de gastrulation \u00e0 l\u2019\u00e9chelle de la cellule unique]. Nature. 2021;600(7888):285-289.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">9.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Petropoulos S, Edsg\u00e4rd D, Reinius B, et al. Single-cell RNA-seq reveals lineage and X chromosome dynamics in human preimplantation embryos [Le s\u00e9quen\u00e7age de l\u2019ARN \u00e0 l\u2019\u00e9chelle de la cellule unique r\u00e9v\u00e8le la dynamique des lign\u00e9es et du chromosome X dans les embryons humains pr\u00e9implantatoires]. Cell. 2016;165(4):1012-1026.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">10.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Blakeley P, Fogarty NM, del Valle I, et al. Defining the three cell lineages of the human blastocyst by single-cell RNA-seq [D\u00e9finition des trois lign\u00e9es cellulaires du blastocyste humain par s\u00e9quen\u00e7age de l\u2019ARN \u00e0 l\u2019\u00e9chelle de la cellule unique]. Development. 2015;142(18):3151-3165.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">11.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Fogarty NME, McCarthy A, Snijders KE, et al. Genome editing reveals a role for OCT4 in human embryogenesis [L\u2019\u00e9dition du g\u00e9nome r\u00e9v\u00e8le le r\u00f4le d\u2019OCT4 dans l\u2019embryogen\u00e8se humaine]. Nature. 2017;550(7674):67-73.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">12.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Rossant J. Genetic control of early cell lineages in the mammalian embryo [Contr\u00f4le g\u00e9n\u00e9tique des premi\u00e8res lign\u00e9es cellulaires chez l\u2019embryon de mammif\u00e8re]. Annu Rev Genet. 2018;52:185-201.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">13.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Arnold SJ, Robertson EJ. Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo [L\u2019engagement cellulaire\u00a0: allocation des lign\u00e9es cellulaires et organisation des axes chez l\u2019embryon pr\u00e9coce de souris]. Nat Rev Mol Cell Biol. 2009;10(2):91-103.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">14.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Tam PPL, Behringer RR. Mouse gastrulation: the formation of a mammalian body plan [Gastrulation chez la souris\u00a0: formation du plan d\u2019organisation d\u2019un mammif\u00e8re]. Mech Dev. 1997;68(1-2):3-25.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">15.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Simunovic M, Brivanlou AH. Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis [Embryo\u00efdes, organo\u00efdes et gastrulo\u00efdes\u00a0: nouvelles approches pour comprendre l\u2019embryogen\u00e8se]. Development. 2017;144(6):976-985.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">16.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Vento-Tormo R, Efremova M, Botting RA, et al. Single-cell reconstruction of the early maternal\u2013fetal interface [Reconstruction de l\u2019interface materno-f\u0153tale pr\u00e9coce \u00e0 l\u2019\u00e9chelle de la cellule unique]. Nature. 2018;563(7731):347-353.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">17.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Turco MY, Moffett A. Development of the human placenta [D\u00e9veloppement du placenta humain]. Development. 2019;146(22):dev163428.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">18.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Aplin JD, Ruane PT. Embryo\u2013epithelium interactions during implantation [Interactions entre l\u2019embryon et l\u2019\u00e9pith\u00e9lium lors de l\u2019implantation]. J Cell Sci. 2017;130(1):15-22.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">19.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy [Implantation et maintien de la grossesse pr\u00e9coce]. N Engl J Med. 2001;345(19):1400-1408.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">20.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Wang H, Dey SK. Roadmap to embryo implantation: clues from mouse models [D\u00e9roulement de l\u2019implantation embryonnaire\u00a0: les enseignements des mod\u00e8les murins]. Nat Rev Genet. 2006;7(3):185-199.<\/cite><\/p>\n<\/div>\n<\/div>\n<div class=\"source-item\">\n<p class=\"main-text-semibold text-black\">21.<\/p>\n<div class=\"source-item-content\">\n<p class=\"main-text-semibold text-black\"><cite>Rossant J, Tam PPL. New insights into early human development: lessons from stem cell models [Nouvelles perspectives sur le d\u00e9veloppement humain pr\u00e9coce\u00a0: enseignements des mod\u00e8les bas\u00e9s sur les cellules souches]. Nat Rev Genet. 2021;22(11):701-713.<\/cite><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"sources-expand-button-wrapper\">\n<div class=\"sources-expand-button\"><svg width=\"32\" height=\"32\" viewbox=\"0 0 32 32\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M8 12L16 20L24 12\" stroke=\"#8C9AAB\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path><\/svg><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Le quatorzi\u00e8me jour du d\u00e9veloppement post-f\u00e9condation chez l&rsquo;\u00eatre humain repr\u00e9sente l&rsquo;une des \u00e9tapes les plus importantes de l&#8217;embryogen\u00e8se pr\u00e9coce. Cette p\u00e9riode marque le d\u00e9but de la gastrulation, au cours de laquelle les trois feuillets embryonnaires \u2013 l&rsquo;ectoderme, le m\u00e9soderme et l&rsquo;endoderme \u2013 se forment \u00e0 partir du disque embryonnaire didermique. Il s&rsquo;agit d&rsquo;une \u00e9tape de [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"template":"","diseases_category":[474],"class_list":["post-8236","diseases_post","type-diseases_post","status-publish","hentry","diseases_category-embryologiques"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.0 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>D\u00e9veloppement embryonnaire humain au 14e jour\u00a0: particularit\u00e9s morphog\u00e9n\u00e9tiques<\/title>\n<meta name=\"description\" content=\"D\u00e9veloppement de l&#039;embryon humain au 14e jour\u00a0: d\u00e9but de la gastrulation, formation des feuillets embryonnaires, de l&#039;amnios et du chorion. D\u00e9tails sur la r\u00e9gulation mol\u00e9culaire et les stades 5 \u00e0 7 de Carnegie.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2e semaine du d\u00e9veloppement embryonnaire&#160;: structure, particularit\u00e9s morphog\u00e9n\u00e9tiques et importance clinico-anatomique\" \/>\n<meta property=\"og:description\" content=\"D\u00e9veloppement de l&#039;embryon humain au 14e jour\u00a0: d\u00e9but de la gastrulation, formation des feuillets embryonnaires, de l&#039;amnios et du chorion. D\u00e9tails sur la r\u00e9gulation mol\u00e9culaire et les stades 5 \u00e0 7 de Carnegie.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/\" \/>\n<meta property=\"og:site_name\" content=\"Voka Wiki\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/VOKA3DAnatomyAndPathology\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-17T12:55:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/3d-diagram-with-numbered-structures-and-legend.webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"12 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/\"},\"author\":{\"name\":\"Daria G.\",\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/#\\\/schema\\\/person\\\/1eda7ebf656a1ad6e3d9234ee6d16568\"},\"headline\":\"2e semaine du d\u00e9veloppement embryonnaire&#160;: structure, particularit\u00e9s morphog\u00e9n\u00e9tiques et importance clinico-anatomique\",\"datePublished\":\"2026-02-26T13:53:00+00:00\",\"dateModified\":\"2026-09-17T12:55:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/\"},\"wordCount\":2584,\"publisher\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/storage.googleapis.com\\\/dev_wiki_voka_io_303011\\\/articles\\\/en\\\/embryology\\\/day-14-of-embryonic-development\\\/3d-diagram-with-numbered-structures-and-legend.webp\",\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/\",\"url\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/\",\"name\":\"D\u00e9veloppement embryonnaire humain au 14e jour\u00a0: particularit\u00e9s morphog\u00e9n\u00e9tiques\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/storage.googleapis.com\\\/dev_wiki_voka_io_303011\\\/articles\\\/en\\\/embryology\\\/day-14-of-embryonic-development\\\/3d-diagram-with-numbered-structures-and-legend.webp\",\"datePublished\":\"2026-02-26T13:53:00+00:00\",\"dateModified\":\"2026-09-17T12:55:22+00:00\",\"description\":\"D\u00e9veloppement de l'embryon humain au 14e jour\u00a0: d\u00e9but de la gastrulation, formation des feuillets embryonnaires, de l'amnios et du chorion. D\u00e9tails sur la r\u00e9gulation mol\u00e9culaire et les stades 5 \u00e0 7 de Carnegie.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/#primaryimage\",\"url\":\"https:\\\/\\\/storage.googleapis.com\\\/dev_wiki_voka_io_303011\\\/articles\\\/en\\\/embryology\\\/day-14-of-embryonic-development\\\/3d-diagram-with-numbered-structures-and-legend.webp\",\"contentUrl\":\"https:\\\/\\\/storage.googleapis.com\\\/dev_wiki_voka_io_303011\\\/articles\\\/en\\\/embryology\\\/day-14-of-embryonic-development\\\/3d-diagram-with-numbered-structures-and-legend.webp\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/14-jour-du-developpement-embryonnaire\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Embryologie\",\"item\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/maladies\\\/embryologiques\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"2e semaine du d\u00e9veloppement embryonnaire&#160;: structure, particularit\u00e9s morphog\u00e9n\u00e9tiques et importance clinico-anatomique\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/\",\"name\":\"Voka Wiki\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/#organization\"},\"alternateName\":\"Anatomy & Pathology Wiki by VOKA\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/#organization\",\"name\":\"Voka 3D Anatomy & Pathology\",\"alternateName\":\"VOKA\",\"url\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/wiki.voka.io\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/cropped-voka-logo-1.png\",\"contentUrl\":\"https:\\\/\\\/wiki.voka.io\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/cropped-voka-logo-1.png\",\"width\":70,\"height\":16,\"caption\":\"Voka 3D Anatomy & Pathology\"},\"image\":{\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/VOKA3DAnatomyAndPathology\\\/\",\"https:\\\/\\\/www.instagram.com\\\/voka.io\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/voka-io\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCqGGuOEpr62ScH8Pjk2q5zw\\\/videos\",\"https:\\\/\\\/www.pinterest.com\\\/VokaAnatomyPro\\\/\",\"https:\\\/\\\/www.threads.com\\\/@voka.io\"],\"description\":\"VOKA.io offers 3D medical animations and custom 3D modeling services. Our product, VOKA 3D Anatomy & Pathology, is a digital atlas with over 1,000 detailed 3D models of human anatomy and pathology, designed for medical education, training, and patient communication.\",\"email\":\"info@voka.io\",\"telephone\":\"+1 814 351 4442\",\"legalName\":\"Voka 3D Anatomy & Pathology\",\"foundingDate\":\"2017-02-12\",\"naics\":\"541512\",\"numberOfEmployees\":{\"@type\":\"QuantitativeValue\",\"minValue\":\"51\",\"maxValue\":\"200\"},\"publishingPrinciples\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/principes-de-publication\\\/\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/wiki.voka.io\\\/fr\\\/#\\\/schema\\\/person\\\/1eda7ebf656a1ad6e3d9234ee6d16568\",\"name\":\"Daria G.\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1faab9091e9e12b98ab4611e0e933edce775a5bbe4d7e27819593886426e21f3?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1faab9091e9e12b98ab4611e0e933edce775a5bbe4d7e27819593886426e21f3?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1faab9091e9e12b98ab4611e0e933edce775a5bbe4d7e27819593886426e21f3?s=96&d=mm&r=g\",\"caption\":\"Daria G.\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"D\u00e9veloppement embryonnaire humain au 14e jour\u00a0: particularit\u00e9s morphog\u00e9n\u00e9tiques","description":"D\u00e9veloppement de l'embryon humain au 14e jour\u00a0: d\u00e9but de la gastrulation, formation des feuillets embryonnaires, de l'amnios et du chorion. D\u00e9tails sur la r\u00e9gulation mol\u00e9culaire et les stades 5 \u00e0 7 de Carnegie.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/","og_locale":"fr_FR","og_type":"article","og_title":"2e semaine du d\u00e9veloppement embryonnaire&#160;: structure, particularit\u00e9s morphog\u00e9n\u00e9tiques et importance clinico-anatomique","og_description":"D\u00e9veloppement de l'embryon humain au 14e jour\u00a0: d\u00e9but de la gastrulation, formation des feuillets embryonnaires, de l'amnios et du chorion. D\u00e9tails sur la r\u00e9gulation mol\u00e9culaire et les stades 5 \u00e0 7 de Carnegie.","og_url":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/","og_site_name":"Voka Wiki","article_publisher":"https:\/\/www.facebook.com\/VOKA3DAnatomyAndPathology\/","article_modified_time":"2026-09-17T12:55:22+00:00","og_image":[{"url":"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/3d-diagram-with-numbered-structures-and-legend.webp","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"12 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/#article","isPartOf":{"@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/"},"author":{"name":"Daria G.","@id":"https:\/\/wiki.voka.io\/fr\/#\/schema\/person\/1eda7ebf656a1ad6e3d9234ee6d16568"},"headline":"2e semaine du d\u00e9veloppement embryonnaire&#160;: structure, particularit\u00e9s morphog\u00e9n\u00e9tiques et importance clinico-anatomique","datePublished":"2026-02-26T13:53:00+00:00","dateModified":"2026-09-17T12:55:22+00:00","mainEntityOfPage":{"@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/"},"wordCount":2584,"publisher":{"@id":"https:\/\/wiki.voka.io\/fr\/#organization"},"image":{"@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/#primaryimage"},"thumbnailUrl":"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/3d-diagram-with-numbered-structures-and-legend.webp","inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/","url":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/","name":"D\u00e9veloppement embryonnaire humain au 14e jour\u00a0: particularit\u00e9s morphog\u00e9n\u00e9tiques","isPartOf":{"@id":"https:\/\/wiki.voka.io\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/#primaryimage"},"image":{"@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/#primaryimage"},"thumbnailUrl":"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/3d-diagram-with-numbered-structures-and-legend.webp","datePublished":"2026-02-26T13:53:00+00:00","dateModified":"2026-09-17T12:55:22+00:00","description":"D\u00e9veloppement de l'embryon humain au 14e jour\u00a0: d\u00e9but de la gastrulation, formation des feuillets embryonnaires, de l'amnios et du chorion. D\u00e9tails sur la r\u00e9gulation mol\u00e9culaire et les stades 5 \u00e0 7 de Carnegie.","breadcrumb":{"@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/#primaryimage","url":"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/3d-diagram-with-numbered-structures-and-legend.webp","contentUrl":"https:\/\/storage.googleapis.com\/dev_wiki_voka_io_303011\/articles\/en\/embryology\/day-14-of-embryonic-development\/3d-diagram-with-numbered-structures-and-legend.webp"},{"@type":"BreadcrumbList","@id":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/14-jour-du-developpement-embryonnaire\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/wiki.voka.io\/fr\/"},{"@type":"ListItem","position":2,"name":"Embryologie","item":"https:\/\/wiki.voka.io\/fr\/maladies\/embryologiques\/"},{"@type":"ListItem","position":3,"name":"2e semaine du d\u00e9veloppement embryonnaire&#160;: structure, particularit\u00e9s morphog\u00e9n\u00e9tiques et importance clinico-anatomique"}]},{"@type":"WebSite","@id":"https:\/\/wiki.voka.io\/fr\/#website","url":"https:\/\/wiki.voka.io\/fr\/","name":"Voka Wiki","description":"","publisher":{"@id":"https:\/\/wiki.voka.io\/fr\/#organization"},"alternateName":"Anatomy & Pathology Wiki by VOKA","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/wiki.voka.io\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/wiki.voka.io\/fr\/#organization","name":"Voka 3D Anatomy & Pathology","alternateName":"VOKA","url":"https:\/\/wiki.voka.io\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/wiki.voka.io\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/wiki.voka.io\/wp-content\/uploads\/2025\/02\/cropped-voka-logo-1.png","contentUrl":"https:\/\/wiki.voka.io\/wp-content\/uploads\/2025\/02\/cropped-voka-logo-1.png","width":70,"height":16,"caption":"Voka 3D Anatomy & Pathology"},"image":{"@id":"https:\/\/wiki.voka.io\/fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/VOKA3DAnatomyAndPathology\/","https:\/\/www.instagram.com\/voka.io\/","https:\/\/www.linkedin.com\/company\/voka-io\/","https:\/\/www.youtube.com\/channel\/UCqGGuOEpr62ScH8Pjk2q5zw\/videos","https:\/\/www.pinterest.com\/VokaAnatomyPro\/","https:\/\/www.threads.com\/@voka.io"],"description":"VOKA.io offers 3D medical animations and custom 3D modeling services. Our product, VOKA 3D Anatomy & Pathology, is a digital atlas with over 1,000 detailed 3D models of human anatomy and pathology, designed for medical education, training, and patient communication.","email":"info@voka.io","telephone":"+1 814 351 4442","legalName":"Voka 3D Anatomy & Pathology","foundingDate":"2017-02-12","naics":"541512","numberOfEmployees":{"@type":"QuantitativeValue","minValue":"51","maxValue":"200"},"publishingPrinciples":"https:\/\/wiki.voka.io\/fr\/principes-de-publication\/"},{"@type":"Person","@id":"https:\/\/wiki.voka.io\/fr\/#\/schema\/person\/1eda7ebf656a1ad6e3d9234ee6d16568","name":"Daria G.","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/secure.gravatar.com\/avatar\/1faab9091e9e12b98ab4611e0e933edce775a5bbe4d7e27819593886426e21f3?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/1faab9091e9e12b98ab4611e0e933edce775a5bbe4d7e27819593886426e21f3?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/1faab9091e9e12b98ab4611e0e933edce775a5bbe4d7e27819593886426e21f3?s=96&d=mm&r=g","caption":"Daria G."}}]}},"_links":{"self":[{"href":"https:\/\/wiki.voka.io\/fr\/wp-json\/wp\/v2\/diseases_post\/8236","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wiki.voka.io\/fr\/wp-json\/wp\/v2\/diseases_post"}],"about":[{"href":"https:\/\/wiki.voka.io\/fr\/wp-json\/wp\/v2\/types\/diseases_post"}],"author":[{"embeddable":true,"href":"https:\/\/wiki.voka.io\/fr\/wp-json\/wp\/v2\/users\/5"}],"wp:attachment":[{"href":"https:\/\/wiki.voka.io\/fr\/wp-json\/wp\/v2\/media?parent=8236"}],"wp:term":[{"taxonomy":"diseases_category","embeddable":true,"href":"https:\/\/wiki.voka.io\/fr\/wp-json\/wp\/v2\/diseases_category?post=8236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}