{"id":3932,"date":"2026-02-26T16:53:46","date_gmt":"2026-02-26T13:53:46","guid":{"rendered":"https:\/\/wiki.voka.io\/glossary\/agonistas-gnrh\/"},"modified":"2026-04-01T18:38:34","modified_gmt":"2026-04-01T15:38:34","slug":"agonistas-gnrh","status":"publish","type":"glossary_item","link":"https:\/\/wiki.voka.io\/es\/glossary\/agonistas-gnrh\/","title":{"rendered":"Agonistas de GnRH"},"content":{"rendered":"\n<p>Los agonistas de GnRH son una clase de f\u00e1rmacos pept\u00eddicos sint\u00e9ticos (triptorelina, goserelina, buserelina) que son an\u00e1logos estructurales de la hormona liberadora de gonadotropina natural del hipot\u00e1lamo, pero con mayor afinidad por los receptores y resistencia a la degradaci\u00f3n enzim\u00e1tica.<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x44D;&#x442;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;-&#x438;-&#x43F;&#x430;&#x442;&#x43E;&#x444;&#x438;&#x437;&#x438;&#x43E;&#x43B;&#x43E;&#x433;&#x438;&#x44F;\"><strong>Etiolog\u00eda y fisiopatolog\u00eda<\/strong><\/h2>\n\n<p>En condiciones fisiol\u00f3gicas, el GnRH es secretado por el hipot\u00e1lamo de forma puls\u00e1til (cada 90 minutos), lo que estimula la liberaci\u00f3n de FSH y LH desde la hip\u00f3fisis. La administraci\u00f3n de formas depot de agonistas establece una concentraci\u00f3n hormonal alta y constante en la sangre. Implementa un mecanismo de acci\u00f3n bif\u00e1sico:<\/p>\n\n<ol class=\"wp-block-list\">\n<li><strong>Fase de estimulaci\u00f3n (flare-up):<\/strong> en los primeros 3-7 d\u00edas se produce una liberaci\u00f3n puntual de gonadotropinas y estradiol.<\/li>\n\n\n\n<li><strong>Fase de desensibilizaci\u00f3n (down-regulation):<\/strong> despu\u00e9s de 10-14 d\u00edas, los receptores de la hip\u00f3fisis pierden sensibilidad y se \u00abinternan\u00bb en la c\u00e9lula. La secreci\u00f3n de FSH y LH se bloquea, los ovarios cesan su funcionamiento, y los niveles de estradiol caen a valores de castraci\u00f3n (menopausia m\u00e9dica reversible).<\/li>\n<\/ol>\n\n<h2 class=\"wp-block-heading\" id=\"h-&#x43A;&#x43B;&#x438;&#x43D;&#x438;&#x447;&#x435;&#x441;&#x43A;&#x43E;&#x435;-&#x437;&#x43D;&#x430;&#x447;&#x435;&#x43D;&#x438;&#x435;\"><strong>Importancia cl\u00ednica<\/strong><\/h2>\n\n<p>Los agonistas de GnRH son la terapia m\u00e1s potente para enfermedades dependientes de hormonas. La hipoestrogenia profunda provoca atrofia de los focos de <strong>endometriosis<\/strong>, el alivio del dolor p\u00e9lvico y la disminuci\u00f3n del volumen del \u00fatero y de los n\u00f3dulos de <strong>miomas<\/strong> en un 30\u201350%. Se utilizan en protocolos de FIV para prevenir la ovulaci\u00f3n prematura. La duraci\u00f3n de la monoterapia est\u00e1 limitada a 6 meses debido al riesgo de desarrollar osteoporosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Los agonistas de GnRH son una clase de f\u00e1rmacos pept\u00eddicos sint\u00e9ticos (triptorelina, goserelina, buserelina) que son an\u00e1logos estructurales de la hormona liberadora de gonadotropina natural del hipot\u00e1lamo, pero con mayor afinidad por los receptores y resistencia a la degradaci\u00f3n enzim\u00e1tica.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-3932","glossary_item","type-glossary_item","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.0 (Yoast SEO v26.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Agonistas de GnRH: definici\u00f3n m\u00e9dica y descripci\u00f3n | Voka Wiki<\/title>\n<meta name=\"description\" content=\"Los agonistas de GnRH son una clase de f\u00e1rmacos 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